Table 3: Change on the serum BUN and creatinine level.

groupSham controlVehicle controlCAPTP 31.25P 62.5P 125LOSA

                   Serum BUN (mg/dL)

Day 01 1 6 . 9 1 ± 1 . 9 9 1 6 . 8 9 ± 1 . 5 3 1 7 . 0 5 ± 2 . 7 2 1 6 . 8 3 ± 1 . 9 7 1 7 . 0 0 ± 2 . 3 0 1 6 . 8 6 ± 1 . 5 3 1 6 . 8 8 ± 2 . 1 6
Day 282 2 0 . 2 4 ± 1 . 8 1 2 0 . 1 0 ± 1 . 5 3 1 8 . 2 4 ± 1 . 1 8 **,## 1 8 . 3 3 ± 1 . 6 8 **,## 1 8 . 2 4 ± 1 . 6 9 ** 1 7 . 3 8 ± 1 . 4 7 *,# 1 7 . 2 5 ± 1 . 4 5 *,#
Day 333 1 9 . 9 3 ± 1 . 8 7 2 0 5 . 9 8 ± 9 8 . 2 7 * 9 4 . 5 3 ± 5 9 . 6 3 *,# 7 2 . 6 6 ± 5 6 . 7 7 # 6 6 . 2 0 ± 5 0 . 5 4 **,# 6 3 . 1 1 ± 3 2 . 3 9 *,# 7 7 . 3 4 ± 4 8 . 6 8 *,#

                   Serum creatinine (mg/dL)

Day 01 0 . 5 5 ± 0 . 0 5 0 . 5 7 ± 0 . 0 3 0 . 5 8 ± 0 . 0 4 0 . 5 6 ± 0 . 0 5 0 . 5 6 ± 0 . 0 3 0 . 5 6 ± 0 . 0 3 0 . 5 7 ± 0 . 0 3
Day 282 0 . 6 3 ± 0 . 0 5 0 . 6 5 ± 0 . 0 5 0 . 6 2 ± 0 . 0 2 0 . 6 1 ± 0 . 0 4 ## 0 . 5 9 ± 0 . 0 3 ## 0 . 5 8 ± 0 . 0 3 **,# 0 . 6 0 ± 0 . 0 3 ##
Day 333 0 . 6 6 ± 0 . 0 6 3 . 7 6 ± 2 . 4 1 * 1 . 6 5 ± 0 . 8 3 *,# 1 . 4 6 ± 0 . 7 2 *,# 1 . 3 0 ± 0 . 6 4 *,# 1 . 1 9 ± 0 . 3 9 *,# 1 . 6 0 ± 0 . 9 8 *,#

𝑛 = 8 ; (Mean ± S.D.), 1first administration day of test article, 2at CDDP administration day, 3at euthanasia; * 𝑃 < 0 . 0 1 and ** 𝑃 < 0 . 0 5 compared to sham by MW test; # 𝑃 < 0 . 0 1 and ## 𝑃 < 0 . 0 5 compared to vehicle control by MW test.