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Figure 1: Different pharmaceutical interventions for VTE target various steps in coagulation cascade. Traditional anticoagulants including unfractionated heparin, low-molecular-weight heparin, and vitamin K antagonists target different steps. Despite, new generation of anticoagulants; rNAPc2 (recombinant nematode anticoagulant protein c2), fondaparinux, rivaroxaban, apixaban, and dabigatran etexilate, have specific targets in coagulation pathways.