Resistance of Platelets in Hypercholesterolemia to Inhibition by Activated Coagulation Factor X

Figure 1

Effect of coagulation factor Xa on aggregation of normal and cholesterol-enriched platelets. Platelets from identical normal donors were studied after platelets were incubated in cholesterol-normal (left) and cholesterol-rich (right) phospholipid dispersion (𝑛=20) (details in METHODS). The effect of a 30 sec exposure of platelets to Tyrode’s buffer with (dark grey) and without (light grey) factor Xa (1 unit/mL) on aggregation by ADP (a), epinephrine (b), and collagen (c). ^∗𝑃<0.05, NS nonsignificant, PRP platelet-rich plasma.

(a)

(b)

(c)