International Scholarly Research Notices

Research Article

Resistance of Platelets in Hypercholesterolemia to Inhibition by Activated Coagulation Factor X

Table 1

Effect of factor Xa on ADP-induced thromboxane A2 synthesis in normal and in vitro cholesterol-enriched platelets.
PRP inAdditionTXA2
(pmol/108 platelets)
Tyrode’s buffer ( 𝑛 = 1 2 )Tyrode’s buffer 8 . 7 ± 2 . 0 𝑃 < 0 . 0 5
Factor Xa 1 . 3 ± 0 . 2
Cholesterol-normal dispersion ( 𝑛 = 1 2 )Tyrode’s buffer 9 . 9 ± 1 . 4 𝑃 < 0 . 0 5
Factor Xa 2 . 0 ± 0 . 3
Cholesterol-rich dispersion ( 𝑛 = 1 2 )Tyrode’s buffer 1 1 . 8 ± 1 . 3 ∗ 𝑃 = NS
Factor Xa 9 . 5 ± 1 . 4
∗ N S compared to PRP in Tyrode’s and cholesterol-normal dispersion.
NS: nonsignificant.