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ISRN Allergy
Volume 2011 (2011), Article ID 169859, 4 pages
http://dx.doi.org/10.5402/2011/169859
Clinical Study

Predictors of Serum Total IgE in a Random Sample of 7–17 Year Old Children

1Department of Respiratory Medicine, Bispebjerg Hospital, 2400 Copenhagen, Denmark
2Department of Dermatology, Bispebjerg Hospital, 2400 Copenhagen, Denmark
3Department of Clinical Biochemistry, Hvidovre Hospital, 2650 Hvidovre, Denmark

Received 7 March 2011; Accepted 11 April 2011

Academic Editors: A. Fukushima and A. S. Zacharasiewicz

Copyright © 2011 Sofie Strømgaard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7–17 year old children, data on possible risk factors were collected using a questionnaire and total serum IgE was measured in venous blood. Airway responsiveness to inhaled histamine was measured and skin prick tests were performed using common aeroallergens. Data was analysed using linear regression. Results. Positive skin prick test ( 𝑃 < . 0 0 1 ), airway hyperresponsiveness ( 𝑃 = . 0 0 3 ), atopic dermatitis ( 𝑃 = . 0 4 6 ), and parental predisposition to allergy ( 𝑃 = . 0 4 7 ) showed a significant relation to serum total IgE levels. There was no association of smoking to serum total IgE. Conclusions. This study showed a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children. In contrast to some earlier studies, we did not find a significant relation between smoking status and IgE.