Modification of a Popular Syngeneic Murine Mammary Tumor Model for Immunotherapy Studies

Figure 6

Tumor formation and growth from the initially implanted and subsequently rechallenged tumor cells. (a) Comparison of tumor growth between 4T1 parental cell line and the established GFP-Luc that does not express HER2. (b) and (c) Comparison of tumor growth between 4T1 parental cell line and the established HER2-expressing C3 (b) and C5 (c) lines. (d) Tumor growth from the rechallenged 4T1 or D2F2/E2 cells in mice that had the original C3 or C5 tumor disappeared. *𝑃<0.01 versus 4T1 tumor.

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