Novel Phenazine 5,10-Dioxides Release •OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo
Figure 1
(a) The chemical structure and proposed mechanism of action of SR4233. (b) The chemical structure of AQ4N. (c) The chemical structures and in vitro biological behaviour of PDOs studied here. SF: survival fraction of V-79 cells treated with PDOs at 20 μM; Phypox: Hypoxic potency, dose which gives 1% of control cell survival in hypoxia; HCR: dose in air divided by the dose in hypoxia giving 1% of control cell survival.
