Novel Phenazine 5,10-Dioxides Release •OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo
Figure 5
Antitumour effects of PDO1 and PDO2. (a) Tumour growth was measured every week and the change in the size was expressed respect to day 0 (beginning of the treatment). Results are expressed as the mean ( per group, statistical analysis was performed using the Student’s unpaired -test, ). Rats were killed on day 29, organs and (b) tumours were removed comparing size and weight of treated and untreated. Histopathology findings (haematoxylin/eosin slides) of PDO1-treated (left) and untreated (right) breast NMU-induced tumours demonstrated: (c) absence of necrosis and vascularisation (arrows) for PDO1 treated (left) and necrosis (circle) for untreated; (d) different tumour compartmentalisation behaviours (presence, left, and absence, right) and micrometastases for untreated (right); (e) differential infiltration of lymphocytes and eosinophils (arrows), significant immune response for PDO1-treated (left) and irrelevant for untreated (left).
