About this Journal Submit a Manuscript Table of Contents
ISRN Allergy
Volume 2011 (2011), Article ID 353045, 5 pages
Clinical Study

Histamine 50-Skin-Prick Test: A Tool to Diagnose Histamine Intolerance

1Private Allergy Clinic Hall i.T., Thurnfeldgasse 3a, 6060 Hall i.T., Austria
2Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck (MUI), Schöpfstraße 41/1, 6020 Innsbruck, Austria

Received 17 December 2010; Accepted 12 January 2011

Academic Editors: N. G. Kounis and Á. Moreno-Ancillo

Copyright © 2011 Lukas Kofler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective. Diagnosis of histamine intolerance until now is based on case history; neither a validated questionnaire nor a routine test is available. It was the aim of this trial to evaluate the usefullness of a prick-test for the diagnosis of histamine intolerance. Methods. Prick-testing with 1% histamine solution and wheal size-measurement to assess the relation between the wheal in prick-test, read after 20 to 50 minutes, as sign of slowed histamine degradation as well as history and symptoms of histamine intolerance. Results. Besides a pretest with 17 patients with HIT we investigated 156 persons (81 with HIT, 75 controls): 64 out of 81 with histamine intolerance(HIT), but only 14 out of 75 persons from the control-group presented with a histamine wheal ≥3 mm after 50 minutes ( 𝑃 < . 0 0 0 1 ). Conclusion and Clinical Relevance. Histamine-50 skin-prickt-test offers a simple tool with relevance.