A Remarkably High-Speed Solution-Phase Combinatorial Synthesis of 2-Substituted-Amino-4-Aryl Thiazoles in Polar Solvents in the Absence of a Catalyst under Ambient Conditions and Study of Their Antimicrobial Activities

Table 2

Screening of solvents for reaction.

Sr. no.	Solvents	Polarity index	Reaction time
1.	DMSO	7.2	25–30 sec
2.	DMF	6.4	30–40 sec
3.	Acetonitrile	5.8	30–40 sec
4.	Ethanol	5.2	60 sec
5.	Methanol	5.1	60 sec
6.	Dioxane	4.8	60 sec
7.	n-butanol	4.0	90 sec
8.	Dichloromethane	3.1	4 min
9.	Carbon tetrachloride	1.6	Not going even after 30 min