Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats

Figure 1

Blood ammonia, glutamine, and urea in rat after the gavage with ammonium acetate and (or) the intraperitoneal administration of cyclophosphamide, mean (SEM), 𝑛=6. Opened circles: sodium acetate; closed circles: sodium acetate + cyclophosphamide; opened squares: ammonium acetate; closed squares: ammonium acetate + cyclophosphamide. Significantly different, 𝑃≤0.05, with (*) sodium acetate group; (#) ammonium acetate group; (†) cyclophosphamide group.

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