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Research Article

Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats

Table 1

Effect of rosmarinic acid (RA) and caffeic acid (CA) on leukocytes of peripheral blood before and after inflammatory process induction.
TreatmentTotal leukocyte (before)Total leukocyte (after)Neutrophils (before)Neutrophils
(after)		Lymphocytes (before)Lymphocytes (after)
Control
𝑛 = 7 		7 3 5 0 ± 3 1 2 7 . 9 1 1 1 7 5 ± 1 6 0 7 . 4 ∗ 1 1 8 3 . 7 5 ± 5 1 9 . 5 4 7 7 9 . 8 3 ± 1 6 6 4 . 9 ∗ ∗ 5 8 2 6 . 7 5 ± 2 5 1 2 5 4 0 1 . 3 ± 9 1 7 . 7 3
RA (5 mg/kg) 𝑛 = 7 7 8 7 5 ± 2 3 3 2 . 7 6 1 2 8 5 0 ± 2 2 0 2 . 9 5 ∗ ∗ 1 7 4 3 . 2 5 ± 8 3 3 . 1 6 6 0 1 3 . 6 ± 1 5 4 8 . 8 5 ∗ ∗ 5 8 1 8 . 7 5 ± 1 9 6 0 6 0 5 4 . 4 2 ± 1 8 1 6 . 6 2
RA (10 mg/kg) 𝑛 = 7 8 8 0 0 ± 1 9 4 5 . 5 1 4 8 0 8 . 3 3 ± 1 1 2 0 . 4 5 ∗ ∗ A 2 0 5 7 . 4 2 ± 7 6 9 . 8 5 B 7 0 0 7 . 1 7 ± 9 9 4 . 9 7 ∗ ∗ B 6 2 7 4 . 4 2 ± 2 2 6 7 . 6 6 7 2 7 0 . 2 5 ± 1 2 9 7 . 2 5 B
CA (5 mg/kg) 𝑛 = 7 9 1 0 0 ± 1 8 0 1 . 4 1 4 0 7 5 ± 1 5 5 3 . 5 7 ∗ ∗ A 1 5 3 0 . 5 6 ± 1 0 2 3 . 2 6 6 5 9 . 8 1 ± 2 0 4 4 . 2 ∗ ∗ 6 8 9 0 . 5 ± 1 5 8 2 . 5 6 3 0 7 . 6 3 ± 1 4 7 8
CA (10 mg/kg) 𝑛 = 7 7 6 2 5 ± 1 9 0 6 . 2 4 1 2 6 5 8 . 3 3 ± 3 5 9 8 . 9 5 ∗ ∗ A 8 2 0 . 5 8 ± 3 8 7 . 2 3 4 7 5 8 . 2 5 ± 2 3 3 7 . 5 4 ∗ ∗ 6 4 7 9 . 3 ± 1 7 4 6 . 4 2 7 3 8 7 . 5 8 ± 1 6 1 5 . 6 3
Mean ± standard error (SEM). Students 𝑡 -test: Compared with control group   A 𝑃 < . 0 5 , B 𝑃 < . 0 1 . Compared between before and after inflammatory induction process ∗ 𝑃 < . 0 5 , ∗ ∗ 𝑃 < . 0 1 .