Next Generation Cancer Protection: The Bivalent HPV Vaccine for Females

Figure 12

Peak anti-HPV-18 titers with Cervarix compared to Cervarix co-administered with a pentavalent vaccine in seronegative females 10–18 years old at study entry [133]. Anti-HPV 18 titers were measured one month after the third dose of Cervarix in the according to protocol immunogenicity cohort of study subjects. Anti HPV 18 seroconversion is equivalent in the two groups studied, represented by the percentages at the base of the columns. The blue line represents the anti-HPV-18 response in women 16–26 years old, and the red dotted line represents the anti-HPV-18 titers in women with natural infection who had cleared their infection (natural infection titers). GMT means geometric mean titer shown with 95% confidence interval bars. EU means ELISA unit. HPV means human papillomavirus vaccine, Cervarix, administered at month 0, 1 and 6. HPV+dTpa-IPV means Cervarix co-administered with diphtheria, tetanus, acellular pertussis and inactivated polio vaccine at month 0,and Cervarix alone administered at months 1 and 6.