Next Generation Cancer Protection: The Bivalent HPV Vaccine for Females

Figure 5

Sustained anti-HPV-18 titers continue through 9.4 years among ATP cohort for immunogenicity [64, 65]. GMT means geometric mean titres for anti-HPV-18 neutralising antibodies by pseudovirion-based neutralisation assay (PBNA). *Horizontal line represents the neutralising antibody level in women from a phase III efficacy study who had cleared a natural infection before enrollment. ATP cohort for immunogenicity means women who met all eligibility criteria, were seronegative at baseline for HPV 16/18 and DNA-negative for 14 oncogenic HPV types at baseline, showed normal cytology, complied with study procedures in preceding and current studies, and had data available for at least one vaccine antibody blood sample. PRE means prevaccination.