Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis

Table 3

Comparison between some clinical manifestation in patients with class IV segmental (S) versus global (G) proliferative lupus nephritis (LN) at the time of renal biopsy.

Clinical manifestation	Class IV-S LN (𝑛=41)	Class IV-G LN (𝑛=22)
number (%) of cases
Mucocutaneous manifestations	28 (68,29%)	12 (54,54%)
40 (63,49%) patients
Pyrexia	11 (39,02%)	19 (68,18%)
30 (51,72%) patients
Musculoskeletal manifestations	16 (26,83%)	15 (86,36%)
31 (49,21%) patients
Gastrointestinal symptoms (lupus hepatitis or pancreatitis)	2 (4,88%)	1 (4,54%)
3 (4,48%) patients
Ascites	2 (4,88%)	3 (13,64%)
5 (7,94%) patients
Pneumonitis	2 (4,88%)	2 (9,09%)
4 (6,35%) patients
Pleural effusion with dyspnoea	4 (9,76%)	7 (31,82%)
11 (17,46%) patients
Cardiovascular symptoms (endocarditis/myocarditis/aortitis)	5 (12,195%)	4 (18,18%)
9 (14,28%) patients
Pericarditis	4 (9,76%)	10 (45,45%)
14 (22,22%) patients
Psychosis	1 (2,44%)	3 (13,64%)
4 (6,35%) patients
Epilepsy	2 (4,88%)	2 (9,09%)
4 (6,35%) patients
Primary ocular manifestations (retinal vasculitis/optic neuritis)	6 (14,63%)	10 (45,45%)
16 (25,4%) patients
Anemia	24 (58,53%)	16 (72,73%)
40 (63,49%) patients
Thrombocytopenia	25 (60,98%)	19 (86,36%)
44 (69,84%) patients
Leukopenia	12 (29,29%)	11 (50%)
23 (36,51%) patients
Lymphopenia	22 (53,68%)	16 (72,73%)
38 (60,32%) patients
Nephrotic syndrome	13 (31,71%)	16 (72,73%)
26 (41,27%) patients