Research Article
Conformational Analysis in 18-Membered Macrolactones Based on Molecular Modeling
Table 2
Energetic difference and Boltzmann population of different conformational types of complexed macrocycles.
| Macrolactone | 18 symmetric () | 18 dissymmetric (, ) | Type | | % | Type | | % |
| | 1 | 0.00 | 28.5 | 8 | 0.00 | 50.1 | to 1โkcal/mol | 8 | 0.30 | 26.5 | | | | | 7 | 0.54 | 25.1 | | | | | 2 | 1.47 | 19.9 | 7 | 4.04 | 18.8 | Sup to1โkcal/mol | | | | 1 | 4.30 | 17.6 | | | | | 2 | 5.39 | 13.5 |
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