The Contribution of Four Immunogenetic Markers for Predicting Persistent Activity in Patients with Recent-Onset Rheumatoid Arthritis or Undifferentiated Arthritis

Table 3

Univariate and multivariate logistic analyses to identify predictors of a disease activity score (DAS28) ≥ 2.6 (yes/no) at one year.

Variables^a	Univariate OR (95% CI)	𝑃 value	Multivariate OR (95% CI)^b	𝑃 value^b
Anti-CCP (neg. versus pos.)	1.84 (0.97, 3.49)	0.062	—	—
RF (neg. versus pos.)	1.59 (0.82, 3.06)	0.169	—	—
SE (−/−versus −/+ or +/+)	4.42 (2.12, 9.22)	< 0.001	4.72 (2.17, 10.25)	<0.001
−308 TNFα (GA/AA versus GG)	1.34 (0.63, 2.84)	0.444	—	—
Classification criteria (UA versus. RA)	1.79 (0.66, 4.82)	0.249	—	—
Number of DMARD	2.44 (1.61, 3.70)	<0.001	2.54 (1.64, 3.95)	<0.001
Corticosteroids (no versus yes)	0.83 (0.26, 1.02)	0.756	—	—
DAS28 ≥ 2.6: 71.60% (95% CI: 69.87%, 73.33%).
𝐺-test for full versus. reduced models: 𝐺 = 2.876; df = 4; 𝑃 = NS.
𝐺-test for logistic model: 𝐺 = 38.243; 𝑑𝑓=2; 𝑃<0.001.
Hosmer-Lemeshow: 𝐶 = 7.124; df = 6; 𝑃=0.310.

^aAll variables measured at baseline, except classification criteria and treatments.
^bValues not shown for variables not retained in the model, that is, those with 𝑃 values ≥ 0.15.
Abbreviations: OR: odds ratio. CI: confidence interval. Anti-CCP: anticyclic citrullinated peptide antibodies. RF: rheumatoid factor. SE: shared epitope. −308 TNFα: G-to-A polymorphism at position 308 of the TNFα gene promoter. UA: undifferentiated arthritis. RA: rheumatoid arthritis. DMARD: disease-modifying antirheumatic drugs.