Research Article
Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
Table 2
Ceftaroline MICs (μg/mL) in the cation-adjusted Mueller-Hinton broth with test variables and agar dilution MICs.
| | | Ceftaroline MICs (μg/mL) in the cation-adjusted Mueller Hinton broth with test variables | | Agar dilution | | | | Ca++ | % NaCl | pH | Inoculum cfu/mL | % serum | | | Incubation | MHA | MHA/ LHB | HTMA | Organism | RMA number | REF | 50 mg/L | 5 | 6 | 8 | 104 | 106 | 10 | 50 | LHB | HTM | CO2 | Anaerobic | | | |
| | ATCC | | | | | | | | | | | | | | | | | E. coli | 25922 | 0.06 | 0.06 | ≤0.008 | 0.125 | 0.06 | 0.06 | 0.125 | 0.06 | 0.125 | 0.125 | 0.125 | 0.125 | 0.03 | 0.06 | 0.25 | 0.25 | 19089 | 0.06 | 0.125 | 0.015 | 0.06 | 0.06 | 0.03 | 0.125 | 0.06 | 0.06 | 0.125 | 0.06 | 0.125 | 0.125 | 0.125 | 0.25 | 0.25 | 19090 | 0.03 | 0.125 | ≤0.008 | 0.06 | 0.03 | 0.03 | 2 | 0.06 | 0.03 | 0.125 | 0.125 | 0.125 | 0.125 | 0.03 | 0.25 | 0.25 |
| K. pneumoniae | 19091 | 0.25 | 0.25 | 0.015 | 0.5 | 0.25 | 0.25 | >8 | 0.25 | 0.125 | 0.25 | 0.5 | 0.5 | 0.25 | 0.125 | 0.25 | 0.5 | 19092 | 0.03 | 0.125 | 0.015 | 0.06 | 0.06 | 0.03 | 0.125 | 0.06 | 0.06 | 0.125 | 0.06 | 0.125 | 0.06 | 0.06 | 0.125 | 0.25 | 19093 | 0.06 | 0.125 | 0.015 | 0.06 | 0.06 | 0.03 | 0.25 | 0.03 | 0.06 | 0.125 | 0.06 | 0.125 | 0.06 | 0.06 | 0.125 | 0.25 |
| | ATCC | | | | | | | | | | | | | | | | | H. influenzae | 49247 | 0.015 | 0.015 | ng | ng | 0.06 | ng | 0.06 | 0.06 | 0.06 | 0.06 | n/t | 0.06 | 0.03 | ng | 0.06 | 0.125 | 16081 | ≤0.008 | ≤0.008 | ng | ng | ≤0.008 | ng | ≤0.008 | ≤0.008 | ≤0.008 | ≤0.008 | n/t | ≤0.008 | ≤0.008 | ng | 0.06 | 0.015 | 18520 | 0.015 | 0.015 | ng | ng | 0.03 | 0.015 | 0.06 | 0.06 | 0.03 | 0.03 | n/t | 0.015 | 0.03 | ng | 0.015 | 0.06 |
| M. catarrhalis | 11940 | 0.125 | 0.06 | ng | ng | 0.125 | 0.03 | 2 | 0.06 | 0.125 | 0.125 | 0.125 | 0.06 | ng | 0.06 | 0.03 | n.g. | 14032 | 0.06 | 0.06 | ng | ng | 0.25 | 0.03 | 1 | 0.125 | 0.25 | 0.125 | 0.125 | 0.25 | ng | 0.06 | 0.03 | 0.03 | 18861 | 0.03 | 0.03 | ng | 0.03 | 0.06 | 0.015 | 2 | 0.25 | 0.25 | 0.125 | 0.06 | 0.25 | ng | 0.03 | 0.015 | 0.06 |
| | ATCC | | | | | | | | | | | | | | | | | S. aureus -MSSA | 29213 | 0.125 | 0.125 | 0.125 | 0.25 | 0.25 | 0.125 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.5 | 18488 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 | 0.125 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.5 | 18401 | 0.125 | 0.125 | 0.125 | 0.25 | 0.125 | 0.125 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 | 0.125 | 0.25 | 0.25 | 0.5 |
| S.aureus -MRSA | 18483 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 0.5 | 0.5 | 1 | 18504 | 0.25 | 0.5 | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.25 | 0.25 | 0.25 | 0.5 | 0.5 | 1 | 18526 | 0.25 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 | 0.5 | 0.5 | 1 |
| | ATCC | | | | | | | | | | | | | | | | | E. faecalis | 29212 | 0.5 | 0.5 | 1 | 0.5 | 1 | 0.5 | 1 | 1 | 1 | 0.5 | 1 | 0.5 | 0.5 | 1 | 0.5 | 2 | 18284 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 4 | 18877 | 1 | 1 | 0.06 | 0.5 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 0.5 | 0.5 | 2 | 0.5 | 4 |
| S. pyogenes | 17018 | 0.002 | 0.002 | ng | 0.002 | 0.002 | 0.002 | 0.004 | 0.002 | 0.002 | n/t | 0.004 | 0.004 | 0.004 | ≤0.008 | ≤0.008 | 0.015 | 17019 | 0.004 | 0.004 | ng | 0.004 | 0.004 | 0.004 | 0.004 | 0.002 | 0.002 | n/t | 0.004 | 0.004 | 0.004 | ≤0.008 | ≤0.008 | 0.015 | 19047 | 0.004 | 0.004 | ng | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | n/t | 0.008 | 0.004 | 0.004 | ≤0.008 | ≤0.008 | 0.015 |
| | ATCC | | | | | | | | | | | | | | | | | S. pneumoniae | 49619 | 0.015 | 0.015 | ng | 0.015 | 0.008 | 0.008 | 0.015 | 0.015 | 0.008 | n/t | 0.015 | 0.015 | 0.015 | ≤0.008 | 0.015 | ≤0.008 | 19094 | 0.004 | 0.004 | ng | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | n/t | 0.008 | 0.004 | 0.004 | ≤0.008 | ≤0.008 | ≤0.008 | 19095 | 0.004 | 0.004 | ng | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | 0.004 | n/t | 0.004 | 0.004 | 0.004 | ≤0.008 | ≤0.008 | ≤0.008 | 13345 | 0.125 | 0.125 | ng | 0.125 | 0.06 | 0.06 | 0.125 | 0.125 | 0.06 | n/t | 0.06 | 0.06 | 0.125 | 0.06 | 0.125 | 0.125 | 13385 | 0.125 | 0.125 | ng | 0.125 | 0.06 | 0.125 | 0.125 | 0.125 | 0.125 | n/t | 0.125 | 0.125 | 0.125 | 0.06 | 0.125 | 0.125 | 18876 | 0.25 | 0.25 | ng | 0.125 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | n/t | 0.25 | 0.25 | 0.125 | 0.125 | 0.25 | 0.25 |
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ATCC: American Type Culture Collection; CFUs: colony-forming units; HTM: Haemophilus test medium; HTMA: HTM with 1.5% agar; LHB: laked horse blood; MHA: Mueller Hinton agar; MIC: minimum inhibitory concentration; MRSA: methicillin-resistant Staphylococcus aureus; MSSA: methicillin-susceptible Staphylococcus aureus; ng: no growth; nt: not tested; REF: reference method; RMA: R.M. Alden (culture collection). All H. influenzae were tested in HTM; all streptococci were tested with 2.5% LHB supplementation.
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