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ISRN Allergy
Volume 2011 (2011), Article ID 818239, 7 pages
http://dx.doi.org/10.5402/2011/818239
Research Article

Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation

Departmento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil

Received 19 August 2011; Accepted 11 September 2011

Academic Editors: A. Horner, B. M. Stadler, and P. E. Taylor

Copyright © 2011 Maria de Lourdes Meirelles Noviello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms.