Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers

Table 2

Saturation solubility of different etoricoxib solid dispersions along with pure etoricoxib and physical mixtures using same carriers (Mean ± SD, n = 3).

Type	Ratio	Saturation solubility (μg/mL)^$
		Physical mixtures	Solid dispersions
	1 : 1	91.65 ± 4.95	124.28 ± 1.93
Etoricoxib : lactose	1 : 5	98.27 ± 5.04	142.26 ± 2.01
	1 :  1	84.91 ± 1.44	107.88 ± 2.87
Etoricoxib : sucrose	1 : 5	89.80 ± 4.12	120.42 ± 2.55
	1 : 1	90.50 ± 5.20	118.82 ± 2.01
Etoricoxib : mannitol	1 : 5	95.76 ± 6.67	131.98 ± 3.48
Pure etoricoxib	—	Saturation solubility (μg/mL)^$
		78.48 ± 1.47

^$Mean ± Standard deviation, n = 3.