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ISRN Vascular Medicine
Volume 2011 (2011), Article ID 827483, 5 pages
http://dx.doi.org/10.5402/2011/827483
Clinical Study

Predisposing Factors for Deep Venous Thrombosis in Children and Adolescents with Nephrotic Syndrome

1State University of Campinas, P.O. Box 6111, 13083-970 Campinas, SP, Brazil
2Department of Pediatric, State University of Campinas, P.O. Box 6111, 13083-970 Campinas, SP, Brazil

Received 17 August 2011; Accepted 28 September 2011

Academic Editor: M. Jayachandran

Copyright © 2011 Gabriela de Toledo Passos Candelaria and Vera Maria Santoro Belangero. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nephrotic syndrome (NS) is a state of hypercoagulability. In this paper, we sought to determine risk factors for the occurrence of deep vein thrombosis (DVT) in children with NS. The “with DVT” group included patients with decompensated NS and diagnosed with DVT. The “without DVT” group included the same patients, six to eighteen months prior to the episode of DVT, with decompensated NS but without DVT. Different prediction variables were analyzed. The odds ratio for the occurrence of DVT in patients with triglyceride levels ≥300 mg/dL was 3.14 (95% CI 1.14 to 8.64). For hematocrit levels ≥43% and for the presence of infection or a severe systemic event, the odds ratio was 4.37 (95% CI 1.23 to 15.53). The presence of significant risk factors for the occurrence of DVT in children with NS may serve as a warning for the occurrence of venous thrombosis.