Modification of a Volume-Overload Heart Failure Model to Track Myocardial Remodeling and Device-Related Reverse Remodeling

Table 1

Mean echocardiographic measurements obtained in each individual sheep during the 1st operation (after mitral chordal disruption), 2nd operation (left ventricular assist device (LVAD) implantation), and 3rd operation (after 11 weeks of LVAD support).

Time	LVDD (mm)	LVSD (mm)	IVS (mm)	PW (mm)	RVDD (mm)	LA (mm)	EF (%)	LV mass (g)
Sheep 1
1st operation (baseline)	32	22	7	7	19	32	55	201
2nd operation (wk 20)	59	44	11	9	26	48	44	570
3rd operation (wk 31)	41	26	11	10	29	48	56	210
Sheep 2
1st operation (baseline)	36	26	9	9	25	36	65	233
2nd operation (wk 20)	68	50	13	11	30	56	50	610
3rd operation (wk 31)	45	30	13	12	35	56	64	236

EF: ejection fraction; IVS: interventricular septal thickness; LA: left atrial dimension; LV: left ventricular; LVDD: left ventricular diastolic dimension; LVSD: left ventricular systolic dimension; PW: posterior wall thickness; RVDD: right ventricular diastolic dimension.