Heart Rate Variability in HIV Patients, Diabetics, and Controls: The AGATAA Study
Table 2
Median (interquartile interval) of the time and frequency domain indices of heart rate variability in HIV-infected patients (treated or not treated with HAART), diabetics, and controls.
HAART (%)
NaΓ―ve
Diabetes (%)
Controls (%)
Time Index
R-R Interval (m/s)
903.1 (758.9β959.5)
908.1 (771.1β1007.5)
883.2 (755.0β933.3)
844.3 (797.1β914.8)
0.55
SDNN (m/s)
26.9 (34.2β64.3)
45.6 (33.0β72.5)
39.1 (25.5β42.7)
45.6 (32.3β62.3)
0.059
pNN50 (%)
3.1 (0.6β11.0)
5.4 (1.0β28.5)
3.4 (0.9β12.0)
7.7 (1.6β20.4)
0.32
r-MSSD (ms)
26.2 (18.5β48.8)
36.5 (25.4β69.2)
25.8 (17.8β40.3)
30.7 (219.2β43.7)
0.36
Low frequency spectral area (ms2)
45.8 (23.1β60.1)
42.2 (33.2β68.2)
25.8 (17.8β40.3)
60.3 (40.3β73.3)
0.06
High frequency spectral area (ms2)
46.2 (31.2β74.1)
47.5 (29.5β60.4)
50.1 (42.1β67.9)
29.5 (21.8β58.2)
0.06
Normalized low frequency area
46.1 (30.6β62.0)
39.9 (28.5β65.7)
42.9 (14.5β57.7)
67.5 (37.9β75.4)
0.04
Normalized high frequency area
45.3 (30.6β67.2)
49.7 (30.4β64.8)
53.5 (34.5β72.2)
27.0 (19.0β57.3)
0.03
LF/HF area
1.1 (0.3β1.7)
0.8 (0.6β2.3)
0.9 (0.3β1.4)
2.3 (0.8β3.3)
0.04
HAART: highly active antiretroviral therapy; SDNN: standard deviation of all NN intervals; pNN50: the proportion derived by a division of the number of pairs of adjacent NN intervals differing by more than 50βms in the entire recording by the total number of all NN intervals; r-MSSD, the square root of the mean of sum of the squares of differences between adjacent NN intervals; LF: low frequency; HF: high frequency. values for differences among the four categories applying F-test for continuous variables and or Chi-square for categorical variables.
*Median (interquartile interval); diabetics β controls, ; diabetics β controls, ; naΓ―ve β controls, ; diabetics β controls, ; naΓ―ve β controls, ; diabetics β controls, ; naΓ―ve β controls, ; diabetics β controls, .