Table 2: Median (interquartile interval) of the time and frequency domain indices of heart rate variability in HIV-infected patients (treated or not treated with HAART), diabetics, and controls.

HAART 𝑁 = 2 9 (%) Naïve 𝑁 = 2 8 Diabetes 𝑁 = 4 4 (%)Controls 𝑁 = 3 0 (%) 𝑃

Time Index

R-R Interval (m/s)903.1 (758.9–959.5)908.1 (771.1–1007.5)883.2 (755.0–933.3)844.3 (797.1–914.8)0.55
SDNN (m/s)26.9 (34.2–64.3)45.6 (33.0–72.5)39.1 (25.5–42.7)45.6 (32.3–62.3)0.059
pNN50 (%)3.1 (0.6–11.0)5.4 (1.0–28.5)3.4 (0.9–12.0)7.7 (1.6–20.4)0.32
r-MSSD (ms)26.2 (18.5–48.8)36.5 (25.4–69.2)25.8 (17.8–40.3)30.7 (219.2–43.7)0.36

Low frequency spectral area (ms2)45.8 (23.1–60.1)42.2 (33.2–68.2)25.8 (17.8–40.3) a 60.3 (40.3–73.3) a 0.06
High frequency spectral area (ms2)46.2 (31.2–74.1)47.5 (29.5–60.4)50.1 (42.1–67.9) b 29.5 (21.8–58.2) b 0.06
Normalized low frequency area46.1 (30.6–62.0)39.9 (28.5–65.7) c 42.9 (14.5–57.7) d 67.5 (37.9–75.4) c , d 0.04
Normalized high frequency area45.3 (30.6–67.2)49.7 (30.4–64.8) e 53.5 (34.5–72.2) f 27.0 (19.0–57.3) e , f 0.03
LF/HF area1.1 (0.3–1.7)0.8 (0.6–2.3) g 0.9 (0.3–1.4) h 2.3 (0.8–3.3) g , h 0.04

HAART: highly active antiretroviral therapy; SDNN: standard deviation of all NN intervals; pNN50: the proportion derived by a division of the number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording by the total number of all NN intervals; r-MSSD, the square root of the mean of sum of the squares of differences between adjacent NN intervals; LF: low frequency; HF: high frequency.
𝑃 values for differences among the four categories applying F-test for continuous variables and or Chi-square for categorical variables.
*Median (interquartile interval);
a diabetics controls, 𝑃 = 0 . 0 0 6 ; b diabetics controls, 𝑃 = 0 . 0 1 ; c naïve controls, 𝑃 = 0 . 0 5 ; d diabetics controls, 𝑃 = 0 . 0 0 4 ; e naïve controls, 𝑃 = 0 . 0 3 ; f diabetics controls, 𝑃 = 0 . 0 0 4 ; g naïve controls, 𝑃 = 0 . 0 2 ; h diabetics controls, 𝑃 = 0 . 0 0 5 .