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ISRN Vascular Medicine
Volume 2011 (2011), Article ID 912820, 9 pages
http://dx.doi.org/10.5402/2011/912820
Review Article

Aspirin in Neurology

1Instituto Nacional de NeurologĂ­a y NeurocirugĂ­a Manuel Velasco SuĂĄrez, Insurgentes Sur 3877, Colonia la Fama, 14269 MĂ©xico, DF, Mexico
2Hospital Angeles Pedregal-Hospital Angeles MĂ©xico, Camino a Santa Teresa 1055, Col. HĂ©roes de Padierna, 10700 MĂ©xico, DF, Mexico

Received 23 September 2011; Accepted 25 October 2011

Academic Editors: J. Jolkkonen, V. Larrue, and P. Tyrrell

Copyright © 2011 Yolanda Aburto-Murrieta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aspirin is widely used for the prevention of recurrent stroke in patients with transient ischaemic attack (TIA) of arterial origin, because it is effective and inexpensive. Clopidogrel and the combination of aspirin and extended-release dipyridamole are more effective than aspirin, but are also much more expensive. No other antithrombotic regimens provide significant advantages over aspirin, although cilostazol and the novel platelet protease-activated receptor-1 antagonist, SCH 530348, are currently being evaluated. Numerous trials have examined the efficacy of antiplatelet drugs, primarily aspirin for prevention of vascular events in patients with a prior TIA or stroke. Although many were small and inconclusive, the Antiplatelet Trialists’ Collaboration (ATC) individual patient data meta-analysis reported that among more than 23000 patients (from 21 randomized controlled trials), antiplatelet therapy (usually aspirin) compared with placebo or untreated control continued for a mean of 29 months was associated with a 22% reduction in the odds of recurrent ischemic stroke, myocardial infarction (MI), or vascular death (17.8% versus 21.4%, 𝑃 = 0 . 0 0 1 ).