Glycogen as a Putative Target for Diagnosis and Therapy in Brain Pathologies

Figure 1

Scheme of some glucose pathways, such as glycolysis, gluconeogenesis, glycogenosis, and glycogenolysis in parallel to ANLSH. The two enzymes that will be targeted by antisense strategy are indicated by full horizontal arrow. Schematic representation of glucose-lactate shuttle between neurons and astrocytes (adapted from [28, 41]). FBPase, fructose-1,6-bisphosphatase; GLAST, GLT-1: Na⁺-glutamate co-transporter; Gln: glutamine; GlnS: glutamine synthetase; Glu: glutamate; GLUT, glucose transporter; GP, glycogen phosphorylase; GS, glycogen synthase; 5-HT, serotonin; Krebs: Krebs cycle; Lac: lactate; LDH5: Lactate dehydrogenase 5; MCT: monocarbohydrate transporter; Mito, mitochondria; NA: noradrenaline; Pyr: pyruvate; VIP: vasointestinal peptide.