Figure 12: MSO effects on monoamine content determined on cerebral cortex of MSO-Fast and MSO-Slow mice. They were given a single MSO dose (75 mg/kg) and were sacrificed thereafter either at various predetermined times or at the onset of seizures (S). (a): Variation of cerebral cortex 5-HT content. (b): Variation of cerebral cortex dopamine content. Significance was given for the total variation of brain monoamine content between the two lines and for value of MSO-Slow mice at the onset of seizures compared to before and after seizures. < 0.05, < 0.01, < 0.001. Values are expressed as mean ± SEM of 20 mice. Data adapted from Cloix et al. .