Glycogen as a Putative Target for Diagnosis and Therapy in Brain Pathologies

Table 1

Summarized data obtained during selection of MSO-Fast and MSO-Slow lines.

Mouse	Step	𝑛	Latency (min)	Seizures (%)	Death (%)	ED50 (mg/kg)
G0	initial	343	420 ± 100	80	37	ND
MSO-Fast	G6	104	320 ± 50	88	12	36,1 ± 0,3
MSO-Slow	G6	80	570 ± 30	5	5	124,9 ± 10,3
MSO-Fast	C8	40	240 ± 20	100	6	41.8 ± 1.6
MSO-Slow	C8	40	600	0	2	>300

Data concerned sensitivity toward MSO (75 mg/kg) of mouse at different levels of generation during the selection process. G0: after mixing of the eight parental strains, G6: after 6 processes of crossing and MSO-challenging, C8: after 8 inbreeding crossings of the selected lines after 10 MSO-challenges. ND: not determined. Data adapted from Cloix et al. [112].