Potential Agents against Plasma Leakage

Figure 1

Interendothelial junctions and focal adhesions Oc = occludin, Cl = claudin, JAM = junctional adhesion molecules, Zho = zonula occludens proteins (zho-1), VE cadherin = vascular endothelial cadherin, β = β catenin, γ = γ catenin, p120 = p120 catenin, Arp = Arp2/3, WASP = Wiskott-Aldrich syndrome protein, Cdc = Cdc42, Vin = vinculin, Px = paxillin, αIn = α integrin, βIn = β integrin, FAK = focal adhesion kinase, Cav = caveolin-1, Fil = filamin, Ten = tensin, – · – · – · – = actin. Oc, Cl, JAM, and Zho are part of tight junctions, while VE cadherin, α, β, γ, p120 catenin are part of adhering junctions that can be modulated by Arp, WASP, and Cdc.