Potential Agents against Plasma Leakage

Figure 4

The role of angiopoetin-1 and slit in barrier maintenance Ang-1 = angiopoetin-1, Tie = Tie2 receptor, Prolea = proleakage mediators, P = phosphorylation, Akt = phosphatidylinositol 3′-kinase/Akt pathway, Robo = Roundabout receptor, NFκB = nuclear factor kappa B, AM incr = adhesion molecule increase, PECAM = PECAM-1, VEcad = VE-cadherin, Cats = catenins, Barrier disr = barrier disruption, solid line = contributing factor, and dashed line = inhibiting factor.