About this Journal Submit a Manuscript Table of Contents
ISRN Neurology
Volume 2012 (2012), Article ID 137873, 4 pages
http://dx.doi.org/10.5402/2012/137873
Research Article

Pathophysiological Evaluation of Cerecyte Coil Embolization for Experimental Broad Neck Aneurysms

1Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Kangawa, Sagamihara 228, Japan
2Center for Genetic Studies of Integrated Biological Functions, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Kangawa, Sagamihara 228, Japan
3Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Kangawa, Sagamihara 228, Japan

Received 5 April 2012; Accepted 23 May 2012

Academic Editors: A. Di Carlo, E. A. Joosten, D. Mathieu, and G. Talamonti

Copyright © 2012 Kazuhisa Iwamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cerecyte second-generation coils feature inner surfaces coated with an absorbable polyglycolic acid (PGA) polymer. Their use is expected to accelerate aneurysm organization, but time course data are limited. The present experimental study was therefore conducted to clarify the processes by pathological examination. Methods. Two types of experimental aneurysms were initially generated in adult mongrel dogs, one bifurcation and another of lateral wall type. Long-term persistence of each was defined by follow-up angiography for more than 1 year. Embolization of the aneurysms was then performed using only cerecyte coils, and follow-up angiography was conducted after 2 and 4 weeks followed by pathological examination. Results. Organization of both types of broad neck aneurysm was apparent 4 weeks after embolization, which is earlier as compared with already reported data for bare coils.