Table 3: The berberine loading percentage onto PLGA nanoparticles prepared by different methods at pH 7.

S.N.Synthesis methodSolvent used for loading drugSurfactant usedBerberine added
Particle size (nm)% drug entrapment

1Single emulsionAcetoneDMAB-0.3%1 mg 1214 50
2Single emulsionAcetonePVA-1%2 mg310 37.5
3Single emulsionDCM and acetone (4 : 1)PVA-1%3 mg276 25
4Double emulsionDCMPVA-1%1 mg182 30
5Double emulsionDCM and acetone (4 : 1)PVA-1%1 mg298 nm40