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ISRN Pharmaceutics
Volume 2012 (2012), Article ID 230621, 7 pages
Research Article

Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride

1Department of Pharmacy, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India
2Bengal College of Pharmaceutical Sciences and Research, Bidhannagar, West Bengal, Durgapur 713212, India

Received 27 March 2012; Accepted 6 June 2012

Academic Editors: J.-J. Chen, J.-M. Huang, and E. Lattmann

Copyright © 2012 Pritam Banerjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Gwen and J. R. Robinson, “Sustained and controlled release drug delivery systems,” in Modern Pharmaceutics, vol. 72, p. 575, Marcel Dekker, New York, NY, USA, 3rd edition, 1996.
  2. W. Y. Thomas and J. R. Robinson, “Controlled release drug delivery system,” in The Science and Practice of Pharmacy, vol. 1, p. 903, 20th edition, 2001.
  3. P. Sriamornsak, “Chemistry of pectin and its pharmaceutical uses : a review,” Silpakorn University International Journal, vol. 3, no. 1-2, pp. 206–228, 2003.
  4. L. S. Liu, Y. J. Won, P. H. Cooke et al., “Pectin/poly(lactide-co-glycolide) composite matrices for biomedical applications,” Biomaterials, vol. 25, no. 16, pp. 3201–3210, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. P. K. Choudhury and M. Kar, “Controlled release metformin hydrochloride microspheres of ethyl cellulose prepared by different methods and study on the polymer affected parameters,” Journal of Microencapsulation, vol. 26, no. 1, pp. 46–53, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Semalty and M. Semalty, “Preparation and characterization of mucoadhesive microspheres of ciprofloxacin hydrochloride,” in Controlled Release Polymeric Formulations, pp. 345–351, American Chemical Society, 1993.
  7. K. N. Shovarni and A. G. Goundalkar, “Preparation and evaluation of microsphere of diclofenac sodium,” Indian Journal of Pharmaceutical Sciences, vol. 56, no. 2, pp. 45–50, 1994. View at Scopus
  8. P. K. Rout and B. S. Nayak, “Formulation design, preparation of losartan potassium microspheres by solvent evaporation method and it's in vitro characterization,” Archives of Pharmaceutical Sciences and Research, vol. 1, no. 1, pp. 166–170, 2009.
  9. M. C. Gohel, R. K. Parikh, and A. Surati, “Preparation and formulation evaluation of diclofenac sodium,” Indian Journal of Pharmaceutical Sciences, vol. 67, no. 5, pp. 575–581, 2005. View at Scopus
  10. D. R. Bhumkar and M. M. Patil, “Studies on effect of variabilities by response methodology for naproxane microspheres,” Indian Drugs, vol. 40, no. 8, pp. 455–461, 2003. View at Scopus
  11. K. Abu-Izza, L. Garcia-Contreras, and D. R. Lu, “Preparation and evaluation of zidovudine-loaded sustained-release microspheres. 2. Optimization of multiple response variables,” Journal of Pharmaceutical Sciences, vol. 85, no. 6, pp. 572–576, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Wang and D. R. Flanagan, “General solution for diffusion-controlled dissolution of spherical particles. 1. Theory,” Journal of Pharmaceutical Sciences, vol. 88, no. 7, pp. 731–738, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Morkhade, S. V. Fulzele, P. M. Satturwar, and S. B. Joshi, “Gum copal and gum damar: Novel matrix forming materials for sustained drug delivery,” Indian Journal of Pharmaceutical Sciences, vol. 68, no. 1, pp. 53–58, 2006. View at Scopus
  14. T. Higuchi, “Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices,” Journal of Pharmaceutical Sciences, vol. 52, no. 12, pp. 1145–1149, 1963. View at Scopus
  15. H. Fesssi, J.-P. Marty, F. Puisieux, and J. T. Carstensen, “The Higuchi square root equation applied to matrices with high content of soluble drug substance,” International Journal of Pharmaceutics, vol. 1, no. 5, pp. 265–274, 1978. View at Publisher · View at Google Scholar
  16. S. Bolton, “Analylisis of varience,” in Pharmaceutical Statistics-Practical and Clinical Application, pp. 235–269, Marcel Dekker, New York, NY, USA, 1997.
  17. K. Rajagopal and K. Sasikala, “Antihyperglycaemic and antihyperlipidaemic effects of Nymphaea stellata in alloxan-induced diabetic rats,” Singapore Medical Journal, vol. 49, no. 2, pp. 137–141, 2008. View at Scopus
  18. P. Daisy and M. Rajathi, “Hypoglycemic effects of Clitoria ternatea Linn. (Fabaceae) in alloxan-induced diabetes in rats,” Tropical Journal of Pharmaceutical Research, vol. 8, no. 5, pp. 393–398, 2009. View at Scopus
  19. R. L. Thies, D. W. Cowens, P. R. Cullis, M. B. Bally, and L. D. Mayer, “Method for rapid separation of liposome-associated doxorubicin from free doxorubicin in plasma,” Analytical Biochemistry, vol. 188, no. 1, pp. 65–71, 1990. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Jain, S. Jain, D. Jain, and M. Amin, “Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation,” Journal of Chromatographic Science, vol. 46, no. 6, pp. 501–504, 2008. View at Scopus
  21. G. R. Chatwal and S. K. Anand, “Infrared absorption spectroscopy,” in Instrumental Methods of Chemical Analysis, pp. 2.29–2.82, Himalayan Publishing House, Mumbai, India, 5th edition, 2005.
  22. W. Kemp, “Infrared spectroscopy,” in Organic Spectroscopy, pp. 19–99, ELBS with Macmillan, Hong Kong, China, 3rd edition, 1996.