Research Article
Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride
Table 2
Physicochemical parameters of microspheres.
| | Formulation | Yield (%)
(X ± SD) | Actual drug content (mg)
(X ± SD) | Theoretical drug content (mg) | Drug entrapment efficiency (%)
(X ± SD) | Particle size (μm)
(X ± SD) | Moisture loss (%) |
| | F1 | | | 66.66 | | | 1.07 | | F2 | | | 50.02 | | | 1.08 | | F3 | | | 40.21 | | | 2.25 | | F4 | | | 33.33 | | | 1.13 | | F5 | | | 28.57 | | | 1.22 | | F6 | | | 28.21 | | | 1.49 | | F7 | | | 25.22 | | | 1.43 | | F8 | | | 26.07 | | | 1.55 | | F9 | | | 50.02 | | | 1.07 | | F10 | | | 50.00 | | | 0.89 | | F11 | | | 51.09 | | | 1.12 | | F12 | | | 50.00 | | | 1.06 |
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Value represent mean ± SD ().
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