Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride

Table 4

Effect of pectin microspheres of metformin HCl on alloxan induced diabetic rats.

Serial number	Design of control	Drug	Blood glucose level mg/dL
			0 hr	1 hr	3 hr	5 hr
1	Diabetic control	—	304.7 ± 5.2	312.3 ± 1.4	301.8 ± 3.5	318.2 ± 7.1
2	Placebo	—	101.2 ± 9.6	134.7 ± 7.1	137.7 ± 5.8	131.9 ± 5.8
3	Pure metformin HCl	25 mg/kg	298.7 ± 6.4	134.4 ± 5.3^*	156.2 ± 7.8^*	205.3 ± 7.8^*
4	Pectin microsphere	25 mg/kg	297.5 ± 13.6	206.1 ± 4.3^*	192.5 ± 5.4^*	173.1 ± 9.3^*

𝑁=6, ^*𝑃<0.001 versus control, values are expressed as mean ± SEM. ^*Statistically significant when compared with diabetic controls (𝑃<0.05).