Immunotherapy of Malignant Disease Using Chimeric Antigen Receptor Engrafted T Cells

Table 1

Targets for CAR-based immunotherapy.

Target	Malignancies	Nature of antigen	Selected references
CD19	B cell	Protein	[39, 44, 151–153]
CD20	B cell	Protein	[154]
CD22	B cell	Protein	[27]
k light chain	B cell	Protein	[155]
CD30	Hodgkin’s and non-Hodgkin’s lymphomas	Protein	[82, 156]
CD33	Myeloid	Protein	[94, 157]
CD123	Myeloid	Protein	[158]
CD38	B cell	Protein	[159, 160]
ROR1	B cell	Protein	[161]
ErbB2	Several, including breast, osteosarcoma, prostate, medulloblastoma, glioblastoma	Protein	[11, 21, 25, 35, 85, 162–173]
ErbB3/4	Several	Protein	[11, 12]
Several ErbB dimers	Several	Protein	[14]
EGFr vIII	Several	Protein	[174]
Carcinoembryonic antigen	Several	Protein	[31, 36, 175]
EGP2	Several	Protein	[176]
EGP40	Colon	Protein	[177]
Mesothelin	Several	Protein	[37, 178]
TAG72	Gastrointestinal	Carbohydrate	[179]
PSMA	Prostate; tumour-associated neovasculature	Protein	[34, 180]
NKG2D ligands	Several	Protein	[181]
B7-H6	Several	Protein	[16]
IL-13 receptor α2	Several	Protein	[136, 182, 183]
MUC1	Breast, ovarian	Heavily glycosylated protein	[22]
MUC16	Ovarian	Heavily glycosylated protein	[184]
CA9	Renal cell carcinoma	Protein	[185]
GD2	Neuroblastoma, Ewing’s sarcoma	Ganglioside	[32, 186, 187]
GD3	Melanoma	Ganglioside	[188]
HMW-MAA	Melanoma	Proteoglycan	[189]
CD171	Neuroblastoma	Protein	[145]
Lewis Y	Several	Carbohydrate	[190]
G250/CAIX	Renal cell carcinoma	Protein	[144]
HLA-A1 MAGE A1	Melanoma	Protein-Peptide complex	[4]
HLA-A2 NY-ESO-1	Several	Protein-Peptide complex	[191]
PSCA	Prostate	Protein	[192]
Folate receptor-α	Ovarian and others	Protein	[193, 194]
CD44v6	Several	Protein	[195]
CD44v7/8	Cervical	Protein	[196]
α vβ 6 integrin	Several	Protein	[13]
8H9	Several	Protein	[197]
NCAM	Neuroblastoma	Protein	[198]
VEGF receptors	Several	Protein	[199, 200]
5T4	Several	Protein	[201]
Foetal AChR	Rhabdomyosarcoma	Protein	[202]
NKG2D ligands	Several	Protein	[72]
CD44v6	Several	Protein	[203]
Dual antigen	Activation by cells that express either targets	Any	[204]
Dual antigen	Maximal activation when both targets expressed	Any	[52]
Universal	All	Any	[18, 19]

AChR: acetylcholine receptor; CA9: carbonic anhydrase 9; EGFr: epidermal growth factor receptor; EGP: epithelial glycoprotein; GD: ganglioside; HWM-MAA: high molecular weight melanoma-associated antigen; MUC: mucin; NCAM: nerve cell adhesion molecule; NKG2D: natural killer group 2 member D; PSCA: prostate stem cell antigen; PSMA: prostate-specific membrane antigen; ROR1: Receptor-tyrosine-kinase-like orphan receptor 1; TAG: tumour-associated glycoprotein; VEGF: vascular endothelial growth factor.