|
| Target | Identifier | Institution | CAR generation | Disease | Comments |
|
| CD19 | NCT01087294 | National Cancer Institute | ? | B cell malignancy | |
| HER2 | NCT00902044 | Baylor College of Medicine | 2 | Sarcoma | |
| K light chain | NCT00881920 | Baylor College of Medicine | 1/2 | B cell/ myeloma | |
| HER2 | NCT01109095 | Baylor College of Medicine | 2 | GBM | Autologous CMV CTLs |
| CD19 | NCT00924326 | National Cancer Institute | 2 | B cell | |
| CD19 | NCT01475058 | Fred Hutchinson Cancer Research Center | 2 | B cell | |
| CD30 | NCT01316146 | Baylor College of Medicine | 2 | Hodgkins/NHL | |
| CD30 | NCT01192464 | Baylor College of Medicine | 1 | CD30+ lymphoma | Autologous EBV CTLs |
| EGFRvIII | NCT01454596 | National Cancer Institute | 3 | Glioma | |
| CD19 | NCT01318317 | City of Hope Medical Center | ? | B cell | |
| HER2 (plus TGFβ Dominant negative receptor) | NCT00889954 | Baylor College of Medicine | 2 | HER2 positive | |
| CD19 | NCT01593696 | National Cancer Institute | 2 | B cell malignancy | |
| GD2 | NCT01460901 | Children’s Mercy Hospital, Kansas City | ? | Neuroblastoma | |
| CD19 | NCT01430390 | Memorial Sloan Kettering Cancer Center | ? | ALL | Donor EBV CTLs post-BMT |
| CD19 | NCT01493453 | Christie Hospital NHS Foundation Trust | 1 | B cell malignancy | Suspended |
| CEA | NCT01212887 | Christie Hospital NHS Foundation Trust | 1 | Multiple | |
| CD19 | NCT01044069 | Memorial Sloan Kettering Cancer Center | 2 | Pre-B-ALL | |
| CD19 | NCT00840853 | Baylor College of Medicine | 2 | B-cell malignancy | Virus-specific CTL [215] |
| CD19 | NCT00586391 | Baylor College of Medicine | 1 and 2 | B-cell malignancy | |
| CD19 | NCT00709033 | Baylor College of Medicine | 2 | B-cell malignancy | |
| PSMA | NCT01140373 | Memorial Sloan Kettering Cancer Center | 2 | Prostate cancer | HSV-TK suicide gene [216] |
| PSMA | NCT00664196 | Roger Williams Medical Center | ? | Prostate cancer | [217] |
| Mesothelin | NCT01355965 | University of Pennsylvania | 2 (4-1BB) | Mesothelioma | Lentiviral vector |
| CD19 | NCT01029366 | University of Pennsylvania | 2 (4-1BB) | B-cell malignancy | Lentiviral vector |
| CD19 | NCT01195480 | University College London | 1 | B-ALL | Donor EBV-CTL post-BMT |
| IL-13Rα2 and HSV-TK | NCT01082926 | City of Hope Medical Center | 1 | Glioma | PET Imaging |
| CD19 | NCT01362452 | MD Anderson Cancer Center | ? | B-cell malignancy | Donor derived after UCBT |
| Extended ErbB family | EudraCT 2012-001654-25 | King’s College London | 2 | Head and neck Cancer | Intratumoral delivery |
| Folate receptor-α | Not known | University of Pennsylvania | 2 (4-1BB) | Ovarian cancer | Lentiviral vector
[218] |
|
