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ISRN Neurology
Volume 2012 (2012), Article ID 279051, 5 pages
http://dx.doi.org/10.5402/2012/279051
Research Article

Ambient Sulphur Dioxide and Female ED Visits for Migraine

Population Studies Division, Health Canada, 269 Laurier Avenue, Room 3-030, Ottawa, ON, Canada K1A 0K9

Received 3 December 2011; Accepted 9 January 2012

Academic Editor: A. Arboix

Copyright © 2012 Mieczysław Szyszkowicz and Eugeniusz Porada. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ambient sulphur dioxide (SO2) concentrations may affect the number of female emergency department (ED) visits for migraine. ED visits diagnosed as migraine among females in two cities in Canada, Toronto ( 𝑁 = 7 0 4 ) and Ottawa ( 𝑁 = 3 , 3 5 8 ), were analyzed. In the study case-crossover design was used. Conditional logistic regression was realized to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) relative to an increase in an interquartile range (IQR, in Toronto I Q R = 2 . 9  ppb, in Ottawa I Q R = 3 . 9  ppb) of sulphur dioxide. In the constructed conditional logistic regression models, temperature and relative humidity were adjusted in the form of natural splines. In Toronto positive and statistically significant associations of sulphur dioxide with migraine ED visits were obtained: all ages, O R = 1 . 0 4 (95% CI: 1.00, 1.08); age group [ 1 5 , 5 0 ] , O R = 1 . 0 5 (95% CI: 1.01, 1.09). In Ottawa positive correlations were observed: all ages, O R = 1 . 0 5 (95% CI: 0.97, 1.13); age group [ 1 5 , 5 0 ] , O R = 1 . 0 6 (95% CI: 0.97, 1.15). The results suggest that female migraine may be affected by ambient sulphur dioxide.