Research Article
Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using - Methylnicotinamide Chloride as a Fluorogenic Agent
Table 1
Optimum conditions for the fluorometric procedure.
| | Drug | pH | NaOH conc. (N) | NaOH volume (mL) | NMNCl conc. (mM) | NMNCl volume (mL) | Cooling time (min) | Heating time (min) | (nm) | (nm) |
| | 1 | 4.0 | 6.0 | 0.7 | 3 × 10−2 | 0.9 | 10 | 3 | 285 | 315 | | 2 | 3.4 | 5.0 | 1.0 | 5 × 10−2 | 1.0 | 20 | 5 | 284 | 315 | | 3 | 4.1 | 1.0 | 0.4 | 4 × 10−2 | 1.0 | 15 | 5 | 279 | 306 | | 4 | 3.9 | 2.0 | 0.6 | 2 × 10−2 | 0.8 | 10 | 4 | 285 | 315 | | 5 | 4.0 | 2.0 | 0.8 | 3 × 10−2 | 1.0 | 12 | 4 | 280 | 307 |
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