Review Article

Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy

Table 2

Temporal changes in antioxidant-associated substances in liver of acatalasemic or normal mice at each sham, 0.5 Gy, or 15 Gy X-ray Irradiation following CCl4 administration. Each value indicates the mean ± SEM. The number of mice experimental points is 5. +++ 𝑃 < 0 . 0 0 1 versus normal mouse * 𝑃 < 0 . 0 5 , *** 𝑃 < 0 . 0 0 1 versus control, # 𝑃 < 0 . 0 5 , ### 𝑃 < 0 . 0 0 1 , versus 𝐶 𝐶 𝑙 4 + S h a m [19].

Mice
TreatmentNormalAcatalasemic

Lipid peroxide level [nmol/mg protein]Control0.39 ± 0.060.49 ± 0.08
C C l 4 + s h a m 1.04 ± 0.20***1.5 ± 0.26***
C C l 4 + 0 . 5 G y 0.80 ± 0.08#1.28 ± 0.18
C C l 4 + 1 5 G y 1.01 ± 0.121.17 ± 0.2

SOD activity [U/mg protein]Control48.6 ± 3.855.5 ± 3.7
C C l 4 + s h a m 20.7 ± 5.0***20.4 ± 3.9***
C C l 4 + 0 . 5 G y 22.0 ± 2.429.1 ± 6.4#
C C l 4 + 1 5 G y 15.2 ± 2.420.7 ± 3.4

Catalase activity [U/mg protein]Control250 ± 25.095 ± 14.5+++
C C l 4 + s h a m 107 ± 23.2***68 ± 13.3*
C C l 4 + 0 . 5 G y 205 ± 14.1###110 ± 10.0###
C C l 4 + 1 5 G y 167 ± 30.9#53 ± 11