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ISRN Cardiology
Volume 2012 (2012), Article ID 292490, 14 pages
http://dx.doi.org/10.5402/2012/292490
Review Article

Glycemic Control during Coronary Artery Bypass Graft Surgery

Department of Cardiothoracic Surgery, The Boston Medical Center and The Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA

Received 25 July 2012; Accepted 26 August 2012

Academic Editors: G. A. Head and A. Politi

Copyright © 2012 Harold L. Lazar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyperglycemia, which occurs in the perioperative period during cardiac surgery, has been shown to be associated with increased morbidity and mortality. The management of perioperative hyperglycemia during coronary artery bypass graft surgery and all cardiac surgical procedures has been the focus of intensive study in recent years. This report will paper the pathophysiology responsible for the detrimental effects of perioperative hyperglycemia during cardiac surgery, show how continuous insulin infusions in the perioperative period have improved outcomes, and discuss the results of trials designed to determine what level of a glycemic control is necessary to achieve optimal clinical outcomes.