Table 2: (a) Number of patients experiencing high grade (Gr 3-4) interferon-related hematologic toxicity during any phase of therapy ( 𝑛 = 2 3 ). (b) Number of patients with high grade (Gr 3-4) interferon-related non-hematologic toxicity reported during any phase of therapy ( 𝑛 = 2 3 ).
(a)

Gr 3Gr 4

Hematologic
 Leukopenia72
 Thrombocytopenia10
 Lymphocytopenia47
 Leukopenia w/fever20

(b)

Gr 3Gr 4

Renal
 Renal failure01
Gastrointestinal
 Elevated LFTs70
 Vomiting10
 Nausea20
 Gallstones10
Neurologic
 Ataxia10
 Dizziness10
 TIA10
 Pain20
 Anxiety10
 Depression40
Constitutional
 Weight loss20
 Fatigue40
 Chills and fever10
Skin
 Rash40
 Pruritis10
 Erythema10
Ocular
 Cotton wool20
 Ulcerated10
 Other ocular toxicity20
Cardiac
 Chest pain10
Pulmonary
 Shortness of breath10