Simulations based on a nonperiodic and a periodic MAPK pathway model are shown on the left-hand and the right-hand side, respectively. Comparisons between the differential equation system and a greedy (a-b) and a hierarchical (c-d) abstraction approach are shown. The results of the DE model are indicted by dashed lines, the agent-based dynamics are depicted as shaded areas. The numbers of agents deployed by the abstraction approaches are compared in (e) and (f) (individual legends are provided in these two diagrams).
