About this Journal Submit a Manuscript Table of Contents
ISRN Spectroscopy
Volume 2012 (2012), Article ID 373215, 6 pages
http://dx.doi.org/10.5402/2012/373215
Research Article

Simple Methods for the Spectrophotometric Determination of Carvedilol

Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri, Karnataka, Mangalore 574 199, India

Received 30 August 2012; Accepted 14 October 2012

Academic Editors: F. Cataldo, C. Kosmidis, and G. Schenk

Copyright © 2012 Divya N. Shetty and B. Narayana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two simple spectrophotometric methods are described for the determination of carvedilol (CAR). Method A is the condensation reaction of CAR with p-dimethylaminobenzaldehyde (PDAB), and the reaction mixture exhibits maximum absorbance at 601 nm. Method B is based on the charge transfer complex formation of CAR with p-chloranil; the color developed is measured at 662 nm. The calibration graphs are found to be linear over 50.00–250.00 and 20.00–100.0 μg mL−1 with molar absorptivity values of and  L mol−1cm−1 for CAR-PDAB and CAR-p-chloranil, respectively. Statistical comparisons of the results are performed with regard to accuracy and precision using Student’s t-test and F-test at 95% confidence level. The methods are successfully employed for the determination of CAR in pharmaceutical preparations, and the results agree favorably with the reference and proposed methods.