Simple Methods for the Spectrophotometric Determination of Carvedilol

Table 2

Analytical parameters.

	Method A	Method B
𝜆max (nm)	601	662
Beer’s law limit (μg mL^−1)	50.00–250.00	20.00–100.00
Molar absorptivity (Lmol^−1 cm^−1)	0.92 × 10^3	0.257 × 10^4
Sandell’s sensitivity (μg cm^−2)	0.050	0.158
Limit of detection** (μg mL^−1)	1.650	0.6626
Limit of quantification** (μg mL^−1)	5.0000	2.0080
Regression equation*	𝑌=𝑎+𝑏𝑋	𝑌=𝑎+𝑏𝑋
Slope (𝑏)	0.0020	0.0049
Intercept (𝑎)	0.0124	0.0203
Correlation coefficient (𝑟)	0.9988	0.9988

* 𝑌 is the absorbance and 𝑋 the concentration in 𝜇g mL⁻¹.
**Calculated according to ICH guidelines.