Simple Methods for the Spectrophotometric Determination of Carvedilol

Table 4

Results of assay of formulations.

Brand name	Carca^a	Carvil^b	Carloc^c
Labeled amount (mg)	3.125	3.125	25.0
Reference value [15]
Percent of label claim ± SD	99.8 ± 0.20	99.92 ± 0.17	98.99 ± 0.18
(1) PDAB
(i) Amount found	3.115	3.110	24.97
(ii) Percent of label claim ± SD	99.7 ± 0.17	99.54 ± 0.26	99.89 ± 0.19
(iii) 𝑡-test	1.73	1.71	1.12
(iv) 𝐹-test	1.38	2.33	1.11
(2) 𝑝-Chloranil
(i) Amount found	3.104	3.134	24.80
(ii) Percent of label claim ± SD	99.35 ± 0.15	100.3 ± 0.15	99.2 ± 0.13
(iii) 𝑡-test	1.73	1.55	2.37
(iv) 𝐹-test	1.77	1.28	1.91

*Mean of four determinations.
^aIntas Pharma, ^bZydus (C&D), ^cCipla Ltd.
Values of 𝑡 at 95% confidence level = 3.182.
Values of 𝐹 at 95% confidence level = 6.39.