Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense)

Figure 1

Study design. Mice were sensitized to pollen proteins by 3 subcutaneous injections, with aluminium hydroxide as adjuvant, separated at 1-week interval. Immunotherapy was conducted during 8 weeks with one treatment per week: one sublingual administration or one 48-h application of Viaskin epicutaneous delivery system. Blood was sampled before immunotherapy (D0) to validate the phase of sensitization and during immunotherapy (D21, D38, D63).