Immunohistochemical Evaluation of Cell Cycle Regulators: Impact on Predicting Prognosis in Stage T1 Urinary Bladder Cancer
Table 3
Univariate and multivariate Cox proportional hazards analysis of recurrence after primary transurethral resection for T1 bladder carcinoma in the southeast healthcare region in Sweden 1992–2001.
Univariate hazard ratio (95% CI)
Multivariate hazard ratio (95% CI)
value**
Tumor size
≤30 mm
1.0
1.0
>30 mm
1.48 (1.09–2.03)
1.51 (1.09–2.09)
0.013
LVI*
No
1.0
1.0
Suspected
1.41 (0.98–2.04)
1.31 (0.88–1.96)
0.19
Yes
2.63 (1.48–4.66)
2.65 (1.43–4.93)
0.002
p16
Abnormal
1.0
1.0
Normal
0.84 (0.61–1.15)
0.92 (0.66–1.27)
0.61
Cyclin D1
Abnormal
1.0
1.0
Normal
0.91 (0.64–1.28)
0.95 (0.67–1.37)
0.80
p21
Abnormal
1.0
1.0
Normal
1.07 (0.75–1.53)
1.18 (0.80–1.77)
0.40
p53
Abnormal
1.0
1.0
Normal
1.71 (1.21–2.42)
1.58 (1.09–2.28)
0.015
MMP2
Abnormal
1.0
1.0
Normal
0.80 (0.55–1.16)
0.79 (0.52–1.20)
0.27
MMP9
Abnormal
1.0
1.0
Normal
0.69 (0.46–1.03)
0.64 (0.42–0.99)
0.046
pRb
Abnormal
1.0
1.0
Normal
0.92 (0.60–1.41)
1.00 (0.64–1.56)
1.0
*LVI: lymphovascular invasion.
**
P values for variables are from multivariate Cox regression after adjusting for each other.
