- About this Journal ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2012 (2012), Article ID 387901, 6 pages
The Relationships between Cholesterol and Suicide: An Update
1Psychiatric Service of Diagnosis and Treatment, Department of Mental Health, “G. Mazzini” Hospital, NHS, ASL 4, 64100 Teramo, Italy
2Department of Neurosciences and Imaging, “G. D’Annunzio” University, 66013 Chieti, Italy
3Pharmaceutical Service, “G. Mazzini” Hospital, NHS, ASL 4, 64100 Teramo, Italy
4IASM, 67100 L’Aquila, Italy
5Department of Clinical Neurosciences, Villa San Benedetto Hospital, Hermanas Hospitalarias, 22032 Albese con Cassano, Italy
6Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy
7Department of Health Science, University of L'Aquila, 67100 L'Aquila, Italy
8Department of Formative Sciences, University of Catania, 95100 Catania, Italy
9Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, School of Medicine, University of Naples “Federico II”, 80121 Naples, Italy
Received 6 November 2012; Accepted 25 November 2012
Academic Editors: C. M. Contreras, B. J. Mitterauer, and C. Norra
Copyright © 2012 Domenico De Berardis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cholesterol is a core component of the central nervous system, essential for the cell membrane stability and the correct functioning of neurotransmission. It has been observed that cholesterol may be somewhat associated with suicidal behaviours. Therefore, the aim of this paper was to elucidate current facts and views about the role of cholesterol levels in mood disorders. The majority of the studies reviewed in the present paper suggest an interesting relationship between cholesterol (especially lower levels) and suicidality. On the other hand, particularly during the last years, relationships between serum cholesterol and suicidality were doubted on the basis of some recent studies that have not found any correlation. However, the debate on relationships between cholesterol and suicide is open and longitudinal studies on a larger sample of patients are needed to further clarify this important issue.
Cholesterol is a core component of the central nervous system (CNS), essential for the cell membrane stability and the correct functioning of neurotransmission . It plays a crucial role in the second messenger systems of the brain that have been associated with the mechanism of action of antidepressant drugs and mood stabilizers and may be involved in the aetiology and pathogenesis of mood disorders [2, 3]. Several studies have shown that patients with major depression (MD) have lower total cholesterol (TC) levels than nondepressed individuals [4, 5]. In addition, lower high-density lipoprotein (HDL-C) cholesterol concentrations and higher ratios of TC/high-density lipoprotein (TC/HDL-C) and low-density lipoprotein/high-density lipoprotein (LDL-C/HDL-C) are also noted in patients with MD [6–8]. It has been observed that cholesterol may be somewhat associated with suicidal behaviours [9, 10]. Moreover, it was found that adiposity together with a high waist-to-hip ratio may be associated with an increased risk of suicide .
All considered, a possible usefulness in evaluating serum cholesterol levels in affective patients may be the prediction of development of suicidal ideation . Therefore, the monitoring of cholesterol may result in a reduction of mortality due to suicidality . However, during the last two years, involvement of serum cholesterol in pathogenesis of MD was doubted on the basis of some recent studies that have not found any correlation between serum cholesterol and depressive symptoms .
Therefore, the aim of the present paper was to elucidate current facts and views about the role of cholesterol levels in suicidality.
2. Studies That Found an Association between Cholesterol and Suicidality
Despite the controversial results about relationships between cholesterol levels and depressed mood, the majority of the literature on this subject seems to show a consistent relationship between cholesterol and suicide [14–20]. The possible relationships between cholesterol levels and suicidality were initially suggested when an excess mortality for violence (suicides and injuries) was observed following the use of cholesterol-lowering drugs [21, 22]. However, even if a meta-analysis conducted by Muldoon et al.  showed that deaths from suicides, accident, and violence were not significantly increased among participants randomised to a cholesterol-lowering intervention compared with those in the control groups, researchers’ attention was focused on this topic.
Despite some lines of evidence of a link between higher cholesterol levels and increased suicidality [11, 24], mainly, as well as for MD, a relationship was found between lower serum cholesterol levels and suicidality [25–27] especially in male gender . Gallerani et al.  published data from a controlled population of 331 parasuicides and found a lower cholesterol level in this group. Sullivan et al.  investigated the association between TC and suicidality in a sample of 90 men and women with MD and found a significant association between lower cholesterol levels and increased suicidality. These findings were confirmed by Kunugi et al.  who similarly found a relationship between low serum cholesterol and suicide attempts and by Papassotiropoulos et al.  who reported that the risk of acute suicidality decreased with increasing TC levels irrespective of age, gender, and nutritional status. Rabe-Jabłońka and Poprawska  determined the level of TC and LDL-cholesterol in blood samples taken from 102 patients with recurrent major depression (according to Diagnostic and Static Manual of Mental Disorders, 4th Edition, DSM-IV) and performed analyses during the acute period of major depression in 3 subgroups: with and without suicidal ideation (S+, S−), and after suicidal attempts (AS), and during remission of depressive symptoms. Moreover, it has been demonstrated that, in acutely depressed patients, low TC and LDL-cholesterol were significantly associated with higher suicide risk. Recently, Olié et al.  tested the clinical applicability of a potential cut-off value in the evaluation of suicidal risk. They found that the risk of suicide attempts increased 7.33-fold in men and 15.6-fold in women in the lowest cholesterol quartile compared to subjects in the highest quartile. Thus, serum cholesterol level may be a strong risk factor for suicidal behavior in patients with depressive symptoms. The authors suggested that total serum cholesterol levels measured at admission may be a useful biological marker of suicidal risk. Also Ruljancic et al.  reported lower serum cholesterol in a sample of MD patients with attempted suicide compared to MD patients without attempted suicides. In a recent study, Troisi  found that attentional impulsiveness (i.e., the inability to focus attention or concentrate, related to executive function deficits and reduced cognitive flexibility), a demonstrated risk factor for suicide, was associated with lower cholesterol levels.
Interestingly, there are some studies that found a low serum cholesterol level especially in violent suicide attempts [36–38]. Vevera et al.  found that patients with a violent suicidal attempt had significantly lower cholesterol levels than patients with nonviolent attempts and the control subjects. They suggested that low levels of cholesterol may be associated with increased tendency for impulsive behaviour and aggression and contribute to a more violent pattern of suicidal behaviour. Tripodianakis et al.  provided further confirmation to this hypothesis and found lower serum cholesterol in violent suicide attempters together with an increased noradrenaline turnover in such subjects. Further observations about relationships between impulsivity and violent behaviour seem to bring other indirect evidence to the connection between lower cholesterol levels and violent suicide attempts [41, 42].
The observation of lower serum cholesterol levels associated with violent suicide attempts seems also to pertain to schizophrenia. In fact, Marčinko et al.  found that schizophrenic patients with a violent suicidal attempt showed significantly lower cholesterol levels and significantly higher cortisol level than patients with nonviolent attempts and control subjects. These findings can be indicative of a more generalized involvement of lower cholesterol levels in violent suicide also in other psychiatric disorders than MD. In fact, concerning suicidality, similar results were found in anorexia nervosa , panic disorder , dissociative disorder , and borderline personality disorder .
It has also been demonstrated that lower cholesterol levels were associated with lifetime suicide attempts . This observation was confirmed by the finding of another study that showed a moderate positive association between cholesterol, triglycerides, body mass index (BMI), and suicide attempts in subjects with depressive symptoms during the past 12 months 
Moreover, it has been reported that lower HDL-C levels (≤40 mg/dL) were associated with an increased prevalence of suicide attempts in women . The finding of a lower HDL-C level in suicide attempters was also confirmed in other studies [51, 52]
Recently, it has been suggested that alexithymia (a personality style characterized by difficulty in identifying and describing feelings together with concrete and poor introspective thinking, frequently but not necessarily associated with depressive symptoms) may be related with cholesterol dysregulation and increased suicidality. In particular, alexithymic individuals with MD and higher suicide risk may show lower HDL-C  and higher triglyceride levels .
3. Neurobiological Mechanism of the Relationships between Cholesterol and Suicidality
In 1992 Engelberg  presented a hypothesis linking cholesterol and the serotonergic system. He hypothesized that a reduced serum cholesterol level may be accompanied by changes in viscosity and function of serotonin receptors and transporters as well as by decreased serotonin precursors that may cause an increase in suicide ideation. Maes et al.  focused their attention on the phenotype of haptoglobin connected with chromosome 16, where the gene encoding lecithin-cholesterol acetyltransferase (LCAT)—the enzyme catalyzing cholesterol esterification in the blood—is located. The authors hypothesized that decreased concentration of esterified cholesterol might be connected with the defect of chromosome 16 that may increase susceptibility to depression by changes in the viscosity of the cellular membrane increasing the risk of aggressive and autoaggressive behaviour.
As consequence of decreased lipid microviscosity in neural membranes, serotonin receptor exposure on the membrane surface may be reduced, with an hypofunction of such receptors. The serotonergic system is strongly recognized as being linked to suicidality and impulsive and aggressive behaviour as lower concentrations of 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) in suicides and suicide attempters were found in several studies . Jokinen et al.  found a significant positive correlation between serum total cholesterol and level of CSF 5-HIAA in suicide attempters that remained significant after correction for age, gender, BMI, and comorbid substance abuse, even if earlier studies did not find an association . These findings were more recently confirmed by Hibbeln et al.  who evaluated TC and CSF 5-HIAA in 42 drug-naïve suicide attempters (with blood samples acquired and lumbar punctures performed in a standardized manner in a controlled study setting) and found a significant positive correlation between serum total cholesterol and level of CSF 5-HIAA.
As suggested by Jokinen et al. , it is also possible that the relationship between cholesterol and the serotonergic system may be a two-way relationship, hypothesis corroborated by the study of Fischer et al.  who found an association between higher LDL levels and the long allele coding for serotonin transporter gene in women.
4. Studies That Did Not Find an Association between Cholesterol and Suicidality
However, especially during the last years, involvement of serum cholesterol in pathogenesis of suicide was doubted on the basis of some studies [61, 62]. For instance, results of a retrospective study conducted on 213 psychiatric inpatients (including 61 patients with affective disorders) did not find significant differences in the serum cholesterol levels between patients who had and had not made a suicide attempt after controlling for age or body mass index . In a prospective study on 92 inpatients with an MD episode at admission, regardless of a significant reduction in depression and suicidality scores, analyses of serum lipid concentrations after 1 and 4 weeks of antidepressant treatment showed no significant differences in lipid levels between patients with and without a history of attempted suicide, even if in patients who used a violent suicide method, there was a trend for lower TC levels compared to those with nonviolent attempt . Further evidence on the lack-of-association hypothesis was also provided by Huang  who evaluated serum lipid profiles, during a 2-year period, in 168 subjects (109 patients with MD and 59 healthy controls) and found that, even if serum lipid profile changes in patients with MD during acute phase were observed, there were no significant differences of any kind in serum lipid profiles between MD patients with or without suicide attempts. The lack of association was also confirmed in a sample of suicidal borderline personality disorder patients who showed no serum cholesterol levels differences between nonsuicidal patients and healthy controls . Moreover, Pompili et al.  reported that nearly lethal resuscitated suicide attempters had no low serum levels of cholesterol and triglycerides compared to patients who had not made a recent suicide attempt.
More recently, de Leon et al.  evaluated 193 current suicide attempters and found that low cholesterol levels were not associated with increased suicide risk but with a decreased risk in men. The lack-of-association hypothesis was substantially confirmed also by Persons et al. .
More recently, D’Ambrosio et al.  did not find any association between serum lipid levels and suicide in patients with bipolar disorder.
The majority of the studies reviewed in the present paper suggested an interesting relationship between cholesterol levels and suicidality, even if a further elucidation of a possible pathophysiological mechanism with regard to cholesterol and suicidality is necessary in future studies. On the other hand, especially during the last years, relationships between serum cholesterol and suicidality were doubted on the basis of some recent studies that have not found any correlation. Although, to date, it is hard to draw a clear conclusion on this topic, it is possible to argue, on the basis of precision of measurements and experimental designs of reviewed studies, that the accuracy of earlier studies, that is, those supporting the hypothesis of a link between cholesterol levels and suicide, was somewhat lower than more recent studies that did not find any relationship. Moreover, it has been observed that changes in plasma cholesterol may be shared by other clinical entities, not clearly corresponding to a peculiarity of suicidality. However, the debate on relationships between cholesterol and suicide is open and longitudinal studies on a larger sample of patients are needed to further clarify this important issue, even if the time to get any conclusive data using longitudinal designs in items such as suicide (among many others) may take longer than the lifespan of the researcher.
|HDL-C:||High-density lipoprotein cholesterol|
|CNS:||Central nervous system|
|LDL-C:||Low-density lipoprotein cholesterol|
|DSM-IV:||Diagnostic and Static Manual of Mental Disorders, 4th Edition|
|BMI:||Body mass index|
- S. N. Ghaemi, G. S. Shields, J. D. Hegarty, and F. K. Goodwin, “Cholesterol levels in mood disorders: high or low?” Bipolar Disorders, vol. 2, no. 1, pp. 60–64, 2000.
- F. Gambi, D. De Berardis, D. Campanella et al., “A retrospective evaluation of the inflammatory marker C-reactive protein (CRP), cholesterol and high-density lipoproteins in patients with major depression: preliminary findings,” European Journal of Inflammation, vol. 3, no. 3, pp. 127–134, 2005.
- D. De Berardis, C. M. Conti, D. Campanella et al., “Evaluation of C-reactive protein and total serum cholesterol in adult patients with bipolar disorder,” International Journal of Immunopathology and Pharmacology, vol. 21, no. 2, pp. 319–324, 2008.
- S. O. Olusi and A. A. Fido, “Serum lipid concentrations in patients with major depressive disorder,” Biological Psychiatry, vol. 40, no. 11, pp. 1128–1131, 1996.
- R. E. Morgan, L. A. Palinkas, E. L. Barrett-Connor, and D. L. Wingard, “Plasma cholesterol and depressive symptoms in older men,” The Lancet, vol. 341, no. 8837, pp. 75–79, 1993.
- H. Shibata, S. Kumagai, S. Watanabe, and T. Suzuki, “Relationship of serum cholesterols and vitamin E to depressive status in the elderly,” Journal of Epidemiology, vol. 9, no. 4, pp. 261–267, 1999.
- G. Cadeddu, P. Fioravanti, R. Antonicelli, P. M. Gasparrini, and R. Gaetti, “Relationship between cholesterol levels and depression in the elderly,” Minerva Medica, vol. 86, no. 6, pp. 251–256, 1995.
- M. Maes, R. Smith, A. Christophe et al., “Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers,” Acta Psychiatrica Scandinavica, vol. 95, no. 3, pp. 212–221, 1997.
- D. De Berardis, C. M. V. Conti, N. Serroni et al., “The role of cholesterol levels in mood disorders and suicide,” Journal of Biological Regulators and Homeostatic Agents, vol. 23, no. 3, pp. 133–140, 2009.
- J. Zhang, “Epidemiological link between low cholesterol and suicidality: a puzzle never finished,” Nutritional Neurosciences, vol. 14, no. 6, pp. 268–287, 2011.
- S. S. Chang, C. P. Wen, M. K. Tsai, D. A. Lawlor, Y. C. Yang, and D. Gunnell, “Adiposity, its related biologic risk factors, and suicide: a cohort study of 542, 088 taiwanese adults,” American Journal of Epidemiology, vol. 175, no. 8, pp. 804–815, 2012.
- J. Fritze, B. Schneider, and M. Lanczik, “Autoaggressive behaviour and cholesterol,” Neuropsychobiology, vol. 26, no. 4, pp. 180–181, 1992.
- U. G. Ö. Ergün, S. Uguz, N. Bozdemir et al., “The relationship between cholesterol levels and depression in the elderly,” International Journal of Geriatric Psychiatry, vol. 19, no. 3, pp. 291–296, 2004.
- J. Brunner, K. G. Parhofer, P. Schwandt, and T. Bronisch, “Cholesterol, essential fatty acids, and suicide,” Pharmacopsychiatry, vol. 35, no. 1, pp. 1–5, 2002.
- D. Lester, “Serum cholesterol levels and suicide: a meta-analysis,” Suicide and Life-Threatening Behavior, vol. 32, no. 3, pp. 333–346, 2002.
- A. Colin, J. Reggers, V. Castronovo, and M. Ansseau, “Lipids, depression and suicide,” Encephale, vol. 29, no. 1, pp. 49–58, 2003.
- A. Apter, N. Laufer, M. Bar-Sever, D. Har-Even, H. Ofek, and A. Weizman, “Serum cholesterol, suicidal tendencies, impulsivity, aggression, and depression in adolescent psychiatric inpatients,” Biological Psychiatry, vol. 46, no. 4, pp. 532–541, 1999.
- N. Ruljancic, M. Mihanovic, and I. Cepelak, “Thrombocyte serotonin and serum cholesterol concentration in suicidal and non-suicidal depressed patients,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 5, pp. 1261–1267, 2011.
- L. F. Ellison and H. I. Morrison, “Low serum cholesterol concentration and risk of suicide,” Epidemiology, vol. 12, no. 2, pp. 168–172, 2001.
- W. Coryell and M. Schlesser, “Combined biological tests for suicide prediction,” Psychiatry Research, vol. 150, no. 2, pp. 187–191, 2007.
- J. Penttinen, “Hypothesis: low serum cholesterol, suicide, and interleukin-2,” American Journal of Epidemiology, vol. 141, no. 8, pp. 716–718, 1995.
- J. R. Hibbeln and N. Salem, “Risks of cholesterol-lowering therapies,” Biological Psychiatry, vol. 40, no. 7, pp. 686–687, 1996.
- M. F. Muldoon, S. B. Manuck, A. B. Mendelsohn, J. R. Kaplan, and S. H. Belle, “Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials,” British Medical Journal, vol. 322, no. 7277, pp. 11–15, 2001.
- S. H. Jee, M. Kivimaki, H. C. Kang, I. S. Park, J. M. Samet, and G. D. Batty, “Cardiovascular disease risk factors in relation to suicide mortality in Asia: prospective cohort study of over one million Korean men and women,” European Heart Journal, vol. 32, no. 22, pp. 2773–2780, 2011.
- M. Sarchiapone, G. Camardese, A. Roy et al., “Cholesterol and serotonin indices in depressed and suicidal patients,” Journal of Affective Disorders, vol. 62, no. 3, pp. 217–219, 2001.
- M. Atmaca, M. Kuloglu, E. Tezcan, B. Ustundag, O. Gecici, and B. Firidin, “Serum leptin and cholesterol values in suicide attempters,” Neuropsychobiology, vol. 45, no. 3, pp. 124–127, 2002.
- P. F. Sullivan, P. R. Joyce, C. M. Bulik, R. T. Mulder, and M. Oakley-Browne, “Total cholesterol and suicidality in depression,” Biological Psychiatry, vol. 36, no. 7, pp. 472–477, 1994.
- J. A. Golier, P. M. Marzuk, A. C. Leon, C. Weiner, and K. Tardiff, “Low serum cholesterol level and attempted suicide,” American Journal of Psychiatry, vol. 152, no. 3, pp. 419–423, 1995.
- M. Gallerani, R. Manfredini, S. Caracciolo, C. Scapoli, S. Molinari, and C. Fersini, “Serum cholesterol concentrations in parasuicide,” British Medical Journal, vol. 310, no. 6995, pp. 1632–1636, 1995.
- H. Kunugi, N. Takei, H. Aoki, and S. Nanko, “Low serum cholesterol in suicide attempters,” Biological Psychiatry, vol. 41, no. 2, pp. 196–200, 1997.
- A. Papassotiropoulos, B. Hawellek, C. Frahnert, G. S. Rao, and M. L. Rao, “The risk of acute suicidality in psychiatric inpatients increases with low plasma cholesterol,” Pharmacopsychiatry, vol. 32, no. 1, pp. 1–4, 1999.
- J. Rabe-Jabłońka and I. Poprawska, “Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission,” Medical Science Monitor, vol. 6, no. 3, pp. 539–547, 2000.
- E. Olié, M. C. Picot, S. Guillaume, M. Abbar, and P. Courtet, “Measurement of total serum cholesterol in the evaluation of suicidal risk,” Journal of Affective Disorders, vol. 133, no. 1-2, pp. 234–238, 2011.
- N. Ruljancic, M. Mihanovic, and I. Cepelak, “Thrombocyte serotonin and serum cholesterol concentration in suicidal and non-suicidal depressed patients,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 5, pp. 1261–1267, 2011.
- A. Troisi, “Low cholesterol is a risk factor for attentional impulsivity in patients with mood symptoms,” Psychiatry Research, vol. 188, no. 1, pp. 83–87, 2011.
- Y. K. Kim and A. M. Myint, “Clinical application of low serum cholesterol as an indicator for suicide risk in major depression,” Journal of Affective Disorders, vol. 81, no. 2, pp. 161–166, 2004.
- J. C. Alvarez, D. Cremniter, P. Lesieur et al., “Low blood cholesterol and low platelet serotonin levels in violent suicide attempters,” Biological Psychiatry, vol. 45, no. 8, pp. 1066–1069, 1999.
- J. C. Alvarez, D. Cremniter, N. Gluck et al., “Low serum cholesterol in violent but not in non-violent suicide attempters,” Psychiatry Research, vol. 95, no. 2, pp. 103–108, 2000.
- J. Vevera, I. Žukov, T. Morcinek, and H. Papežová, “Cholesterol concentrations in violent and non-violent women suicide attempters,” European Psychiatry, vol. 18, no. 1, pp. 23–27, 2003.
- J. Tripodianakis, M. Markianos, D. Sarantidis, and M. Agouridaki, “Biogenic amine turnover and serum cholesterol in suicide attempt,” European Archives of Psychiatry and Clinical Neuroscience, vol. 252, no. 1, pp. 38–43, 2002.
- F. Pozzi, A. Troisi, M. Cerilli et al., “Serum cholesterol and impulsivity in a large sample of healthy young men,” Psychiatry Research, vol. 120, no. 3, pp. 239–245, 2003.
- E. Repo-Tiihonen, P. Halonen, J. Tiihonen, and M. Virkkunen, “Total serum cholesterol level, violent criminal offences, suicidal behavior, mortality and the appearance of conduct disorder in Finnish male criminal offenders with antisocial personality disorder,” European Archives of Psychiatry and Clinical Neuroscience, vol. 252, no. 1, pp. 8–11, 2002.
- D. Marčinko, M. Martinac, D. Karlović et al., “Are there differences in serum cholesterol and cortisol concentrations between violent and non-violent schizophrenic male suicide attempters?” Collegium Antropologicum, vol. 29, no. 1, pp. 153–157, 2005.
- A. Favaro, L. Caregaro, L. Di Pascoli, F. Brambilla, and P. Santonastaso, “Total serum cholesterol and suicidality in anorexia nervosa,” Psychosomatic Medicine, vol. 66, no. 4, pp. 548–552, 2004.
- O. A. Özer, R. Kutanis, M. Y. Agargun et al., “Serum lipid levels, suicidality, and panic disorder,” Comprehensive Psychiatry, vol. 45, no. 2, pp. 95–98, 2004.
- M. Y. Agargun, O. A. Özer, H. Kara, R. Şekeroğlu, Y. Selvi, and B. Eryonucu, “Serum lipid levels in patients with dissociative disorder,” American Journal of Psychiatry, vol. 161, no. 11, pp. 2121–2123, 2004.
- M. Atmaca, M. Kuloglu, E. Tezcan, O. Gecici, and B. Ustundag, “Serum cholesterol and leptin levels in patients with borderline personality disorder,” Neuropsychobiology, vol. 45, no. 4, pp. 167–171, 2002.
- J. G. Fiedorowicz and W. H. Coryell, “Cholesterol and suicide attempts: a prospective study of depressed inpatients,” Psychiatry Research, vol. 152, no. 1, pp. 11–20, 2007.
- J. Brunner, T. Bronisch, H. Pfister, F. Jacobi, M. Höfler, and H. U. Wittchen, “High cholesterol, triglycerides, and body-mass index in suicide attempters,” Archives of Suicide Research, vol. 10, no. 1, pp. 1–9, 2006.
- J. Zhang, R. E. McKeown, J. R. Hussey, S. J. Thompson, J. R. Woods, and B. E. Ainsworth, “Low HDL cholesterol is associated with suicide attempt among young healthy women: the Third National Health and Nutrition Examination Survey,” Journal of Affective Disorders, vol. 89, no. 1–3, pp. 25–33, 2005.
- D. Marcinko, V. Marcinko, D. Karlović et al., “Serum lipid levels and suicidality among male patients with schizoaffective disorder,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 1, pp. 193–196, 2007.
- J. Jokinen, A. L. Nordström, and P. Nordström, “Cholesterol, CSF 5-HIAA, violence and intent in suicidal men,” Psychiatry Research, vol. 178, no. 1, pp. 217–219, 2010.
- D. De Berardis, N. Serroni, D. Campanella et al., “Alexithymia and its relationships with C-reactive protein and serum lipid levels among drug naïve adult outpatients with major depression,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 8, pp. 1982–1986, 2008.
- K. Paplos, B. Havaki-Kontaxaki, P. Ferentinos, M. Dasopoulou, and V. Kontaxakis, “Alexithymia, depression and serum lipids in suicide attempters,” Psychiatrike, vol. 23, no. 2, pp. 149–152, 2012.
- H. Engelberg, “Low serum cholesterol and suicide,” The Lancet, vol. 339, no. 8795, pp. 727–729, 1992.
- M. Maes, J. Delanghe, H. Y. Meltzer, S. Scharpe, P. D. D'Hondt, and P. Cosyns, “Lower degree of esterification of serum cholesterol in depression: relevance for depression and suicide research,” Acta Psychiatrica Scandinavica, vol. 90, no. 4, pp. 252–258, 1994.
- A. Troisi, “Cholesterol in coronary heart disease and psychiatric disorders: same or opposite effects on morbidity risk?” Neuroscience and Biobehavioral Reviews, vol. 33, no. 2, pp. 125–132, 2009.
- D. L. Ringo, S. E. Lindley, K. F. Faull, and W. O. Faustman, “Cholesterol and serotonin: seeking a possible link between blood cholesterol and CSF 5-HIAA,” Biological Psychiatry, vol. 35, no. 12, pp. 957–959, 1994.
- J. R. Hibbeln, J. C. Umhau, D. T. George, S. E. Shoaf, M. Linnoila, and N. Salem, “Plasma total cholesterol concentrations do not predict cerebrospinal fluid neurotransmitter metabolites: implications for the biophysical role of highly unsaturated fatty acids,” American Journal of Clinical Nutrition, vol. 71, no. 1, supplement, pp. 331–338, 2000.
- P. Fischer, E. Gruenblatt, P. Pietschmann, and K. H. Tragl, “Serotonin transporter polymorphism and LDL-cholesterol,” Molecular Psychiatry, vol. 11, no. 8, pp. 707–709, 2006.
- L. G. Almeida-Montes, V. Valles-Sanchez, J. Moreno-Aguilar et al., “Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts,” Journal of Psychiatry and Neuroscience, vol. 25, no. 4, pp. 371–377, 2000.
- S. Y. M. Tsai, C. J. Kuo, C. C. Chen, and H. C. Lee, “Risk factors for completed suicide in bipolar disorder,” Journal of Clinical Psychiatry, vol. 63, no. 6, pp. 469–476, 2002.
- T. L. Huang, “Serum cholesterol levels in mood disorders associated with physical violence or suicide attempts in Taiwanese,” Chang Gung Medical Journal, vol. 24, no. 9, pp. 563–568, 2001.
- E. A. Deisenhammer, K. Kramer-Reinstadler, D. Liensberger, G. Kemmler, H. Hinterhuber, and W. W. Fleischhacker, “No evidence for an association between serum cholesterol and the course of depression and suicidality,” Psychiatry Research, vol. 121, no. 3, pp. 253–261, 2004.
- T. L. Huang, “Serum lipid profiles in major depression with clinical subtypes, suicide attempts and episodes,” Journal of Affective Disorders, vol. 86, no. 1, pp. 75–79, 2005.
- D. Marčinko, V. Bilić, N. Pivac et al., “Serum cholesterol concentration and structured individual psychoanalytic psychotherapy in suicidal and non-suicidal male patients suffering from borderline personality disorder,” Collegium Antropologicum, vol. 35, supplement 1, pp. 219–233, 2011.
- M. Pompili, M. Innamorati, D. Lester, P. Girardi, and R. Tatarelli, “Nearly lethal resuscitated suicide attempters have no low serum levels of cholesterol and triglycerides,” Psychological Reports, vol. 106, no. 3, pp. 785–790, 2010.
- J. de Leon, P. Mallory, L. Maw, M. T. Susce, M. M. Perez-Rodriguez, and E. Baca-Garcia, “Lack of replication of the association of low serum cholesterol and attempted suicide in another country raises more questions,” Annals of Clinical Psychiatry, vol. 23, no. 3, pp. 163–170, 2011.
- J. E. Persons, W. H. Coryell, and J. G. Fiedorowicz, “Cholesterol fractions, symptom burden, and suicide attempts in mood disorders,” Psychiatry Research, vol. 200, no. 2-3, pp. 1088–1089, 2012.
- V. D'Ambrosio, V. Salvi, F. Bogetto, and G. Maina, “Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 37, no. 1, pp. 136–140, 2012.