Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage

Table 2

Effect of gentamicin and ursolic acid on serum urea, uric acid, creatinine, and blood urea nitrogen levels.

Parameters	Control group	Gentamicin group	Ursolic acid; 2 mg/kg	Ursolic acid; 5 mg/kg	Ursolic acid; 10 mg/kg
Serum urea (mg/dL)	41.17±0.703	162.33±9.922^∗	137.83±4.643^∗∗	99±2.646^∗∗	41.33±2.692^∗∗
Serum uric acid (mg/dL)	1.62±0.305	3.13±0.123^∗	2.42±0.108^∗∗	1.57±0.128^∗∗	1.32±0.14^∗∗
Serum Creatinine (mg/dL)	0.58±0.075	6.85±0.348^∗	5.63±0.390^∗∗	2.42±0.295^∗∗	0.92±0.054^∗∗
Blood urea nitrogen levels (mg/dL)	19.24±0.329	75.86±4.636^∗	64.41±2.17^∗∗	46.26±1.236^∗∗	19.31±1.258^∗∗

Values are mean ± SEM.
^∗𝑃<0.001 when compared to the normal control.
^∗∗𝑃<0.001 when compared to gentamicin induced nontreated disease control.